Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling

Marion Régnier; Arnaud Polizzi; Tiffany Fougeray; Anne Fougerat; Prunelle Perrier; Karen Anderson; Yannick Lippi; Sarra Smati; Céline Lukowicz; Frédéric Lasserre; Edwin Fouche; Marine Huillet; Clémence Rives; Blandine Tramunt; Claire Naylies; Géraldine Garcia; Elodie Rousseau-Bacquié; Justine Bertrand-Michel; Cécile Canlet; Sylvie Chevolleau-Mege; Laurent Debrauwer; Christophe Heymes; Rémy Burcelin; Thierry Levade; Pierre Gourdy; Walter Wahli; Yuna Blum; Laurence Gamet-Payrastre; Sandrine Ellero-Simatos; Julie Guillermet-Guibert; Phillip Hawkins; Len Stephens; Catherine Postic; Alexandra Montagner; Nicolas Loiseau; Hervé Guillou

doi:10.1371/journal.pbio.3003112

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Open Access

Peer-reviewed

Research Article

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling

Marion Régnier,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliations Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France, Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France

https://orcid.org/0000-0002-5005-0597

⨯
Arnaud Polizzi,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0003-1986-2770

⨯
Tiffany Fougeray,

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Anne Fougerat,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Prunelle Perrier,

Roles Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Karen Anderson,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom
⨯
Yannick Lippi,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0003-4717-078X

⨯
Sarra Smati,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Céline Lukowicz,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Frédéric Lasserre,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Edwin Fouche,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Marine Huillet,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0002-6508-4351

⨯
Clémence Rives,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Blandine Tramunt,

Roles Formal analysis, Investigation, Methodology

Affiliations Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France, Diabetology Department, CHU de Toulouse, Toulouse, France
⨯
Claire Naylies,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Géraldine Garcia,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Elodie Rousseau-Bacquié,

Roles Investigation, Methodology, Resources

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Justine Bertrand-Michel,

Roles Formal analysis, Methodology, Resources

Affiliations Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France, Metatoul-Lipidomic Facility, MetaboHUB, Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France
⨯
Cécile Canlet,

Roles Formal analysis, Methodology, Resources

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Sylvie Chevolleau-Mege,

Roles Formal analysis, Investigation, Methodology

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France
⨯
Laurent Debrauwer,

Roles Formal analysis, Investigation, Methodology, Resources

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0003-3600-0902

⨯
Christophe Heymes,

Roles Formal analysis, Investigation, Methodology

Affiliation Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France
⨯
Rémy Burcelin,

Roles Investigation, Methodology, Resources

Affiliation Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France
⨯
Thierry Levade,

Roles Formal analysis, Investigation, Methodology, Resources, Supervision

Affiliations Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm U1037, CNRS U5071, Université de Toulouse, Toulouse, France, Laboratoire de Biochimie, CHU de Toulouse, Toulouse, France
⨯
Pierre Gourdy,

Roles Funding acquisition, Investigation, Resources, Supervision

Affiliations Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France, Diabetology Department, CHU de Toulouse, Toulouse, France

https://orcid.org/0000-0002-5362-3813

⨯
Walter Wahli,

Roles Resources, Supervision, Writing – review & editing

Affiliations Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore, Center for Integrative Genomics, Université de Lausanne, Lausanne, Switzerland

https://orcid.org/0000-0002-5966-9089

⨯
Yuna Blum,

Roles Data curation, Formal analysis, Methodology, Software

Affiliation Univ Rennes, CNRS, INSERM, IGDR (Institut de Génétique et Développement de Rennes) – UMR6290, ERL U1305, Rennes, France
⨯
Laurence Gamet-Payrastre,

Roles Investigation, Methodology, Resources, Supervision

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0003-1681-8491

⨯
Sandrine Ellero-Simatos,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0002-9282-1804

⨯
Julie Guillermet-Guibert,

Roles Methodology, Resources, Supervision

Affiliation Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm U1037, CNRS U5071, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0003-3173-4907

⨯
Phillip Hawkins,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision

Affiliation The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom

https://orcid.org/0000-0002-6979-0464

⨯
Len Stephens,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision

Affiliation The Signaling Programme, The Babraham Institute, Cambridge, United Kingdom
⨯
Catherine Postic,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France

https://orcid.org/0000-0002-1875-6960

⨯
Alexandra Montagner,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, Université de Toulouse, Inserm, Toulouse, France

https://orcid.org/0000-0002-4800-5105

⨯
Nicolas Loiseau ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

* E-mail: nicolas.loiseau@inrae.fr (NL); herve.guillou@inrae.fr (HG)

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0003-3783-0879

⨯
[ ... ],
Hervé Guillou

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft

* E-mail: nicolas.loiseau@inrae.fr (NL); herve.guillou@inrae.fr (HG)

Affiliation Toxalim (Research Center in Food Toxicology), INRAE, ENVT, INP-PURPAN, UMR1331, Université de Toulouse, Toulouse, France

https://orcid.org/0000-0002-5363-9081

⨯
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Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling

Marion Régnier,
Arnaud Polizzi,
Tiffany Fougeray,
Anne Fougerat,
Prunelle Perrier,
Karen Anderson,
Yannick Lippi,
Sarra Smati,
Céline Lukowicz,
Frédéric Lasserre

Published: April 14, 2025
https://doi.org/10.1371/journal.pbio.3003112

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