Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells

Ioanna Oikonomidi; Vasumathi Kameswaran; Victoria C. Pham; Iratxe Zuazo-Gaztelu; Lauren M. Gutgesell; Scot Marsters; Bence Daniel; Jennie R. Lill; Zora Modrusan; Avi Ashkenazi

doi:10.1371/journal.pbio.3003096

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Open Access

Peer-reviewed

Research Article

Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells

Ioanna Oikonomidi,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Research Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Vasumathi Kameswaran,

Roles Investigation, Methodology

Affiliation Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, California, United States of America
⨯
Victoria C. Pham,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, California, United States of America
⨯
Iratxe Zuazo-Gaztelu,

Roles Investigation

Affiliation Department of Research Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Lauren M. Gutgesell,

Roles Data curation, Investigation

Affiliation Department of Research Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Scot Marsters,

Roles Methodology, Resources

Affiliation Department of Research Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Bence Daniel,

Roles Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, California, United States of America
⨯
Jennie R. Lill,

Roles Supervision

Affiliation Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, California, United States of America
⨯
Zora Modrusan,

Roles Supervision

Affiliation Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, California, United States of America
⨯
Avi Ashkenazi

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: aa@gene.com

Affiliation Department of Research Oncology, Genentech, Inc., South San Francisco, California, United States of America

https://orcid.org/0000-0002-6890-4589

⨯

Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells

Ioanna Oikonomidi,
Vasumathi Kameswaran,
Victoria C. Pham,
Iratxe Zuazo-Gaztelu,
Lauren M. Gutgesell,
Scot Marsters,
Bence Daniel,
Jennie R. Lill,
Zora Modrusan,
Avi Ashkenazi

Published: April 11, 2025
https://doi.org/10.1371/journal.pbio.3003096

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Cell cycle and cell division
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Phosphorylation
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Multiple myeloma
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