Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

Sheng Huang; Chengji Piao; Zhiying Zhao; Christine B. Beuschel; Oriane Turrel; David Toppe; Stephan J. Sigrist

doi:10.1371/journal.pbio.3003076

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Open Access

Peer-reviewed

Research Article

Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

Sheng Huang ,

Contributed equally to this work with: Sheng Huang, Chengji Piao

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: sheng.huang@fu-berlin.de (SH); stephan.sigrist@fu-berlin.de (SJS)

Affiliations Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany
⨯
Chengji Piao ,

Contributed equally to this work with: Sheng Huang, Chengji Piao

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany
⨯
Zhiying Zhao,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany
⨯
Christine B. Beuschel,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany
⨯
Oriane Turrel,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany
⨯
David Toppe,

Roles Formal analysis, Investigation

Affiliation Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany
⨯
Stephan J. Sigrist

Roles Funding acquisition, Project administration, Resources

* E-mail: sheng.huang@fu-berlin.de (SH); stephan.sigrist@fu-berlin.de (SJS)

Affiliations Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany

https://orcid.org/0000-0002-1698-5815

⨯

Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

Sheng Huang,
Chengji Piao,
Zhiying Zhao,
Christine B. Beuschel,
Oriane Turrel,
David Toppe,
Stephan J. Sigrist

Published: March 20, 2025
https://doi.org/10.1371/journal.pbio.3003076

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Drosophila melanogaster
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Sleep
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Memory
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Heterozygosity
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PKA signaling cascade
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Phenotypes
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Learning and memory
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