Monocyte-secreted Wnt reduces the efficiency of central nervous system remyelination

• Bianca M. Hill ,

  Contributed equally to this work with: Bianca M. Hill, Rebecca K. Holloway, Lindsey H. Forbes, Claire L. Davies

  Affiliations Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada, BARLO Multiple Sclerosis Centre, St. Michael’s Hospital, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada

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• Rebecca K. Holloway ,

  Contributed equally to this work with: Bianca M. Hill, Rebecca K. Holloway, Lindsey H. Forbes, Claire L. Davies

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada, BARLO Multiple Sclerosis Centre, St. Michael’s Hospital, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada

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• Lindsey H. Forbes ,

  Contributed equally to this work with: Bianca M. Hill, Rebecca K. Holloway, Lindsey H. Forbes, Claire L. Davies

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Claire L. Davies ,

  Contributed equally to this work with: Bianca M. Hill, Rebecca K. Holloway, Lindsey H. Forbes, Claire L. Davies

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Jonathan K. Monteiro,

  Affiliations Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada, BARLO Multiple Sclerosis Centre, St. Michael’s Hospital, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada

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• Christina M. Brown,

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Jamie Rose,

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Neva Fudge,

  Affiliation Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada

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• Pamela J. Plant,

  Affiliation Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada

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• Ayisha Mahmood,

  Roles Investigation, Writing – review & editing

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Koroboshka Brand-Arzamendi,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada, BARLO Multiple Sclerosis Centre, St. Michael’s Hospital, Toronto, Ontario, Canada

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• Sarah A. Kent,

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Irene Molina-Gonzalez,

  Roles Investigation, Writing – review & editing

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

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• Stefka Gyoneva,

  Roles Methodology, Writing – review & editing

  Affiliation Previously at Biogen Ltd, Cambridge, Massachusetts, United States of America

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• Richard M. Ransohoff,

  Roles Conceptualization, Methodology, Project administration, Writing – review & editing

  Affiliations Previously at Biogen Ltd, Cambridge, Massachusetts, United States of America, Third Rock Ventures, Boston, Massachusetts, United States of America

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• Brian Wipke,

  Roles Conceptualization, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliations Previously at Biogen Ltd, Cambridge, Massachusetts, United States of America, Manifold Bio, Boston, Massachusetts, United States of America

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• Josef Priller,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliations United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Clinical Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany, Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin and DZNE, Berlin, Germany

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• Raphael Schneider,

  Roles Investigation, Methodology, Project administration, Writing – review & editing

  Affiliations Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada, BARLO Multiple Sclerosis Centre, St. Michael’s Hospital, Toronto, Ontario, Canada

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• Craig S. Moore,

  Affiliation Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada

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•  [ ... ],
• Veronique E. Miron

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: veronique.miron@unityhealth.to

  Affiliations Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada, BARLO Multiple Sclerosis Centre, St. Michael’s Hospital, Toronto, Ontario, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada, United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, United Kingdom, Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh, Edinburgh, Scotland, United Kingdom

  https://orcid.org/0000-0003-1738-0647

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