Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice

• Dongdong Zhao ,

  Contributed equally to this work with: Dongdong Zhao, Yuanhui Huo, Naizhen Zheng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhaoddcns@163.com (DZ); yunzhang@xmu.edu.cn (Y-wZ)

  Affiliations Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Yuanhui Huo ,

  Contributed equally to this work with: Dongdong Zhao, Yuanhui Huo, Naizhen Zheng

  Roles Formal analysis, Funding acquisition, Investigation, Methodology

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Naizhen Zheng ,

  Contributed equally to this work with: Dongdong Zhao, Yuanhui Huo, Naizhen Zheng

  Roles Formal analysis, Investigation, Methodology

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Xiang Zhu,

  Roles Investigation, Methodology, Validation

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

  ⨯
• Dingting Yang,

  Roles Investigation, Methodology, Validation

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

  ⨯
• Yunqiang Zhou,

  Roles Methodology

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

  ⨯
• Shengya Wang,

  Roles Methodology

  Affiliation Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China

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• Yiru Jiang,

  Roles Methodology

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

  ⨯
• Yili Wu,

  Roles Methodology, Supervision

  Affiliation Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China

  ⨯
• Yun-wu Zhang

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhaoddcns@163.com (DZ); yunzhang@xmu.edu.cn (Y-wZ)

  Affiliation Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

  https://orcid.org/0000-0002-7152-7630

  ⨯