The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses

• Ya Wang ,

  Contributed equally to this work with: Ya Wang, Chun Hin Chow

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

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• Chun Hin Chow ,

  Contributed equally to this work with: Ya Wang, Chun Hin Chow

  Roles Data curation, Investigation

  Affiliations Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, Canada, Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Yu Zhang,

  Roles Data curation, Investigation

  Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Mengjia Huang,

  Roles Data curation, Investigation

  Affiliations Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, Canada, Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Randa Higazy,

  Roles Data curation, Investigation

  Affiliations Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, Canada, Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Neeraja Ramakrishnan,

  Roles Investigation

  Affiliation Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Lili Chen,

  Roles Investigation

  Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Xuhui Chen,

  Roles Data curation, Investigation

  Affiliation Key Laboratory of Vascular Aging of the Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Yixiang Deng,

  Roles Data curation, Investigation

  Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Sheng Wang,

  Roles Data curation, Supervision

  Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Cuntai Zhang,

  Roles Supervision, Validation

  Affiliation Key Laboratory of Vascular Aging of the Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Cong Ma ,

  Roles Investigation, Supervision, Validation, Writing – review & editing

  * E-mail: cong.ma@hust.edu.cn (CM); Shuzo.Sugita@uhnresearch.ca (SS); sgao@hust.edu.cn (SG)

  Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Shuzo Sugita ,

  Roles Conceptualization, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: cong.ma@hust.edu.cn (CM); Shuzo.Sugita@uhnresearch.ca (SS); sgao@hust.edu.cn (SG)

  Affiliations Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Ontario, Canada, Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Shangbang Gao

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: cong.ma@hust.edu.cn (CM); Shuzo.Sugita@uhnresearch.ca (SS); sgao@hust.edu.cn (SG)

  ¶‡ Lead contact.

  Affiliations Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China, Key Laboratory of Vascular Aging of the Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

  https://orcid.org/0000-0001-5431-4628

  ⨯