Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex

• Shun Hao ,

  Contributed equally to this work with: Shun Hao, Man Xue, Qi-Yu Chen

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China, Zhuomin Institute of Brain Research, Forevercheer Medicine Pharmac Inc., Qingdao, Shandong, China

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• Man Xue ,

  Contributed equally to this work with: Shun Hao, Man Xue, Qi-Yu Chen

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China

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• Qi-Yu Chen ,

  Contributed equally to this work with: Shun Hao, Man Xue, Qi-Yu Chen

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

  Affiliations CAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China, Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan, China

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• Jinjin Wan,

  Roles Investigation, Methodology

  Affiliation Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China

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• Yu-Jie Ma,

  Roles Investigation, Methodology

  Affiliation Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China

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• Wantong Shi,

  Roles Investigation, Methodology

  Affiliation Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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• Xuanying Chen,

  Roles Methodology

  Affiliation Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China

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• Xu-Hui Li,

  Roles Investigation, Methodology

  Affiliation Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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• Jing-Shan Lu,

  Roles Methodology, Resources

  Affiliation Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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• Fang Xu,

  Roles Methodology

  Affiliation CAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

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• Guo-Qiang Bi,

  Roles Resources

  Affiliation CAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

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• Wucheng Tao,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China

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• Min Zhuo

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: minzhuo10@gmail.com

  Affiliations Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China, Zhuomin Institute of Brain Research, Forevercheer Medicine Pharmac Inc., Qingdao, Shandong, China, Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, Ontario, Canada

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