HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice

• Ayaka Watanabe ,

  Contributed equally to this work with: Ayaka Watanabe, Shoshiro Hirayama

  Roles Data curation, Formal analysis, Investigation, Writing – original draft

  Affiliation Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  ⨯
• Shoshiro Hirayama ,

  Contributed equally to this work with: Ayaka Watanabe, Shoshiro Hirayama

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

  Affiliation Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  ⨯
• Itsuki Kominato,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  ⨯
• Sybille Marchese,

  Roles Formal analysis, Resources, Software, Writing – review & editing

  Affiliation School of Biology, University of St Andrews, St Andrews, United Kingdom

  ⨯
• Pietro Esposito,

  Roles Resources, Writing – review & editing

  Affiliation School of Biology, University of St Andrews, St Andrews, United Kingdom

  ⨯
• Vanya Metodieva,

  Roles Resources, Writing – review & editing

  Affiliation School of Biology, University of St Andrews, St Andrews, United Kingdom

  ⨯
• Taeko Kimura,

  Roles Data curation, Writing – original draft

  Affiliation Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  ⨯
• Hiroshi Kameda,

  Roles Investigation, Writing – original draft

  Affiliation Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan

  ⨯
• Terunori Sano,

  Roles Data curation, Resources

  Affiliation Department of Clinical Laboratory, National Centre of Neurology and Psychiatry, Tokyo, Japan

  ⨯
• Masaki Takao,

  Roles Data curation, Funding acquisition, Resources

  Affiliation Department of Clinical Laboratory, National Centre of Neurology and Psychiatry, Tokyo, Japan

  ⨯
• Sho Takatori,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  ⨯
• Masato Koike,

  Roles Funding acquisition, Resources

  Affiliation Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan

  ⨯
• Juan Alberto Varela,

  Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation School of Physics and Astronomy, University of St Andrews, St Andrews, United Kingdom

  ⨯
• Taisuke Tomita,

  Roles Funding acquisition, Methodology, Supervision

  Affiliation Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  ⨯
• Shigeo Murata

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: smurata@g.ecc.u-tokyo.ac.jp

  Affiliation Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

  https://orcid.org/0000-0002-3177-3503

  ⨯