The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity

• Liam C. Hunt,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Current address: Department of Biology, Rhodes College, Memphis, Tennessee, United States of America

  Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Michelle Curley,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Kudzai Nyamkondiwa,

  Roles Data curation, Investigation

  Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Anna Stephan,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Jianqin Jiao,

  Roles Investigation

  Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Kanisha Kavdia,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Vishwajeeth R. Pagala,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Junmin Peng,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliations Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Fabio Demontis

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Fabio.Demontis@stjude.org

  Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-8698-9555

  ⨯