VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy

• Huaji Jiang ,

  Contributed equally to this work with: Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Writing – original draft

  Affiliations Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China, Department of Orthopaedics, Yue Bei People’s Hospital Affiliated to Shantou University Medical College, Shaoguan, Guangdong, China

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• Yingchao Xie ,

  Contributed equally to this work with: Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu

  Roles Data curation, Investigation, Methodology, Writing – original draft

  Affiliation Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

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• Zhiqiang Hu ,

  Contributed equally to this work with: Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu

  Roles Data curation, Methodology

  Affiliations Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China, Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China

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• Jiansen Lu ,

  Contributed equally to this work with: Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China, Department of Joint Surgery, the Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China

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• Jiahuan Zhang,

  Roles Data curation, Investigation, Methodology

  Affiliations Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China, Department of Clinical Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China

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• Hongyu Li,

  Roles Investigation, Methodology

  Affiliation Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

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• Ke Zeng,

  Roles Methodology

  Affiliation Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

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• Wenqiang Peng,

  Roles Methodology

  Affiliation Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

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• Cheng Yang,

  Roles Investigation, Resources

  Affiliation Department of Orthopaedics, Yue Bei People’s Hospital Affiliated to Shantou University Medical College, Shaoguan, Guangdong, China

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• Junsheng Huang,

  Roles Methodology

  Affiliations First School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, Youth Medical Association of Macao, Macao, China

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• Zelong Han ,

  Roles Conceptualization, Investigation, Project administration

  * E-mail: hzl1988@smu.edu.cn (ZH); baixc15@smu.edu.cn (XB); xiaoyu523@smu.edu.cn (XY)

  Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

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• Xiaochun Bai ,

  Roles Conceptualization, Project administration

  * E-mail: hzl1988@smu.edu.cn (ZH); baixc15@smu.edu.cn (XB); xiaoyu523@smu.edu.cn (XY)

  Affiliation Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

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• Xiao Yu

  Roles Conceptualization, Funding acquisition, Project administration, Validation, Writing – original draft, Writing – review & editing

  * E-mail: hzl1988@smu.edu.cn (ZH); baixc15@smu.edu.cn (XB); xiaoyu523@smu.edu.cn (XY)

  Affiliations Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China, Department of Clinical Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China

  https://orcid.org/0000-0003-2491-9110

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