Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice

Kenji Uno; Takuya Uchino; Takashi Suzuki; Yohei Sayama; Naoki Edo; Kiyoko Uno-Eder; Koji Morita; Toshio Ishikawa; Miho Koizumi; Hiroaki Honda; Hideki Katagiri; Kazuhisa Tsukamoto

doi:10.1371/journal.pbio.3002955

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Open Access

Peer-reviewed

Research Article

Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice

Kenji Uno ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: unok@med.teikyo-u.ac.jp, unok@h4.dion.ne.jp

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

https://orcid.org/0000-0002-9362-9232

⨯
Takuya Uchino,

Roles Formal analysis

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
⨯
Takashi Suzuki,

Roles Formal analysis

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
⨯
Yohei Sayama,

Roles Formal analysis

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
⨯
Naoki Edo,

Roles Formal analysis

Affiliation Teikyo Academic Research Center, Tokyo, Japan
⨯
Kiyoko Uno-Eder,

Roles Formal analysis

Affiliation Teikyo Academic Research Center, Tokyo, Japan
⨯
Koji Morita,

Roles Formal analysis

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
⨯
Toshio Ishikawa,

Roles Formal analysis

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
⨯
Miho Koizumi,

Roles Resources

Affiliation Field of Human Disease Models, Tokyo Women’s Medical University, Tokyo, Japan
⨯
Hiroaki Honda,

Roles Resources

Affiliation Field of Human Disease Models, Tokyo Women’s Medical University, Tokyo, Japan
⨯
Hideki Katagiri,

Roles Resources

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Kazuhisa Tsukamoto

Roles Formal analysis

Affiliation Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
⨯

Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice

Kenji Uno,
Takuya Uchino,
Takashi Suzuki,
Yohei Sayama,
Naoki Edo,
Kiyoko Uno-Eder,
Koji Morita,
Toshio Ishikawa,
Miho Koizumi,
Hiroaki Honda

Published: January 24, 2025
https://doi.org/10.1371/journal.pbio.3002955

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