Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants

Lavisha Parab; Jordan Romeyer Dherbey; Norma Rivera; Michael Schwarz; Jenna Gallie; Frederic Bertels

doi:10.1371/journal.pbio.3002952

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Open Access

Peer-reviewed

Research Article

Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants

Lavisha Parab ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: parab@evolbio.mpg.de (LP); bertels@evolbio.mpg.de (FB)

Affiliation Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany

https://orcid.org/0000-0002-7626-3216

⨯
Jordan Romeyer Dherbey,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany
⨯
Norma Rivera,

Roles Investigation

Affiliation Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany
⨯
Michael Schwarz,

Roles Investigation

Affiliation Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany
⨯
Jenna Gallie,

Roles Data curation, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Microbial Evolutionary Dynamics Group, Department of Theoretical Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany

https://orcid.org/0000-0003-2918-0925

⨯
Frederic Bertels

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: parab@evolbio.mpg.de (LP); bertels@evolbio.mpg.de (FB)

Affiliation Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany
⨯

Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants

Lavisha Parab,
Jordan Romeyer Dherbey,
Norma Rivera,
Michael Schwarz,
Jenna Gallie,
Frederic Bertels

Published: January 21, 2025
https://doi.org/10.1371/journal.pbio.3002952

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Bacteriophages
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Antibiotics
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Chloramphenicol
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Escherichia coli
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Antibiotic resistance
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Phenotypes
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