Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa

• Joseph T. Ortega,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Jacklyn M. Gallagher,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft

  Affiliations The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, United States of America, Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America

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• Andrew G. McKee,

  Roles Data curation, Formal analysis, Validation, Writing – original draft

  Affiliation Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America

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• Yidan Tang,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America

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• Miguel Carmena-Bargueňo,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), UCAM Universidad Católica de Murcia, Guadalupe, Spain

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• Maria Azam,

  Roles Data curation, Formal analysis, Validation, Visualization, Writing – original draft

  Affiliation Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Zaiddodine Pashandi,

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Marcin Golczak,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Jens Meiler,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft

  Affiliations Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America, Institute for Drug Discovery, Leipzig University, Leipzig, Germany

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• Horacio Pérez-Sánchez,

  Roles Data curation, Funding acquisition, Methodology, Supervision, Writing – original draft

  Affiliation Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), UCAM Universidad Católica de Murcia, Guadalupe, Spain

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• Jonathan P. Schlebach,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft

  Affiliation The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, United States of America

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• Beata Jastrzebska

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bxj27@case.edu

  Affiliation Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0001-5209-8685

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