Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

Montserrat Llanses Martinez; Keqian Nan; Zhe Bao; Rachele Bacchetti; Shengnan Yuan; Joe Tyler; Xavier Le Guezennec; Frederic A. Bard; Elena Rainero

doi:10.1371/journal.pbio.3002930

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Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

Montserrat Llanses Martinez,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliations School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom, Institute of Molecular and Cell Biology, Singapore, Singapore
⨯
Keqian Nan ,

Contributed equally to this work with: Keqian Nan, Zhe Bao

Roles Investigation, Methodology

Affiliation School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom
⨯
Zhe Bao ,

Contributed equally to this work with: Keqian Nan, Zhe Bao

Roles Investigation, Methodology

Affiliation School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom
⨯
Rachele Bacchetti,

Roles Investigation, Methodology

Affiliation School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom
⨯
Shengnan Yuan,

Roles Investigation

Affiliation School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom
⨯
Joe Tyler,

Roles Data curation, Investigation, Methodology

Affiliation School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom
⨯
Xavier Le Guezennec,

Roles Methodology, Supervision, Writing – review & editing

Affiliation Institute of Molecular and Cell Biology, Singapore, Singapore
⨯
Frederic A. Bard,

Roles Funding acquisition, Supervision

Affiliations Institute of Molecular and Cell Biology, Singapore, Singapore, Centre de Recherche en Cancérologie de Marseille, CRCM, Marseille, France
⨯
Elena Rainero

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: e.rainero@sheffield.ac.uk

Affiliation School of Biosciences, University of Sheffield, Western Bank, Sheffield, United Kingdom

https://orcid.org/0000-0003-1402-8701

⨯

Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

Montserrat Llanses Martinez,
Keqian Nan,
Zhe Bao,
Rachele Bacchetti,
Shengnan Yuan,
Joe Tyler,
Xavier Le Guezennec,
Frederic A. Bard,
Elena Rainero

Published: December 12, 2024
https://doi.org/10.1371/journal.pbio.3002930

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