Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments

Jyoti Tanwar; Kriti Ahuja; Akshay Sharma; Paras Sehgal; Gyan Ranjan; Farina Sultan; Anushka Agrawal; Donato D’Angelo; Anshu Priya; Vamsi K. Yenamandra; Archana Singh; Anna Raffaello; Muniswamy Madesh; Rosario Rizzuto; Sridhar Sivasubbu; Rajender K. Motiani

doi:10.1371/journal.pbio.3002895

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Research Article

Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments

Jyoti Tanwar,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India

https://orcid.org/0000-0001-9610-6405

⨯
Kriti Ahuja,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India
⨯
Akshay Sharma,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India
⨯
Paras Sehgal,

Roles Formal analysis, Investigation

Affiliation CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Gyan Ranjan,

Roles Formal analysis, Investigation

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India
⨯
Farina Sultan,

Roles Formal analysis, Validation

Current address: CSIR-Indian Institute of Integrative Medicine, Jammu, India

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India
⨯
Anushka Agrawal,

Roles Formal analysis, Investigation

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India
⨯
Donato D’Angelo,

Roles Formal analysis, Investigation, Visualization

Affiliation Department of Biomedical Sciences, University of Padua, Padua, Italy
⨯
Anshu Priya,

Roles Formal analysis, Investigation, Visualization

Affiliation CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Vamsi K. Yenamandra,

Roles Resources

Affiliation CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Archana Singh,

Roles Formal analysis, Visualization

Affiliation CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Anna Raffaello,

Roles Formal analysis, Visualization

Affiliation Department of Biomedical Sciences, University of Padua, Padua, Italy
⨯
Muniswamy Madesh,

Roles Resources

Affiliation Department of Medicine, Center for Mitochondrial Medicine, Cardiology Division, University of Texas Health San Antonio, San Antonio, Texas, United States of America
⨯
Rosario Rizzuto,

Roles Resources

Affiliations Department of Biomedical Sciences, University of Padua, Padua, Italy, National Center on Gene Therapy and RNA-Based Drugs, Padua, Italy
⨯
Sridhar Sivasubbu,

Roles Resources

Affiliation CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
[ ... ],
Rajender K. Motiani

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rajender.motiani@rcb.res.in

Affiliation Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India

https://orcid.org/0000-0002-8971-9008

⨯
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Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments

Jyoti Tanwar,
Kriti Ahuja,
Akshay Sharma,
Paras Sehgal,
Gyan Ranjan,
Farina Sultan,
Anushka Agrawal,
Donato D’Angelo,
Anshu Priya,
Vamsi K. Yenamandra

Published: November 11, 2024
https://doi.org/10.1371/journal.pbio.3002895

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B16 cells
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Melanocytes
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