Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity

• Yasir Malik ,

  Contributed equally to this work with: Yasir Malik, Yavuz Kulaberoglu, Shajahan Anver

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Biosciences, University of Kent, Canterbury, United Kingdom

  ⨯
• Yavuz Kulaberoglu ,

  Contributed equally to this work with: Yasir Malik, Yavuz Kulaberoglu, Shajahan Anver

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  ⨯
• Shajahan Anver ,

  Contributed equally to this work with: Yasir Malik, Yavuz Kulaberoglu, Shajahan Anver

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  ⨯
• Sara Javidnia,

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  ⨯
• Gillian Borland,

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Rene Rivera,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation School of Biosciences, University of Kent, Canterbury, United Kingdom

  ⨯
• Stephen Cranwell,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  ⨯
• Danel Medelbekova,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  ⨯
• Tatiana Svermova,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  ⨯
• Jackie Thomson,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Susan Broughton,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom

  ⨯
• Tobias von der Haar,

  Roles Conceptualization, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Biosciences, University of Kent, Canterbury, United Kingdom

  ⨯
• Colin Selman ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: colin.selman@glasgow.ac.uk (CS); j.m.a.tullet@kent.ac.uk (JMAT); n.alic@ucl.ac.uk (NA)

  Affiliation School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Jennifer M. A. Tullet ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: colin.selman@glasgow.ac.uk (CS); j.m.a.tullet@kent.ac.uk (JMAT); n.alic@ucl.ac.uk (NA)

  Affiliation School of Biosciences, University of Kent, Canterbury, United Kingdom

  https://orcid.org/0000-0002-2037-526X

  ⨯
• Nazif Alic

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: colin.selman@glasgow.ac.uk (CS); j.m.a.tullet@kent.ac.uk (JMAT); n.alic@ucl.ac.uk (NA)

  Affiliation Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom

  https://orcid.org/0000-0003-0356-6600

  ⨯