Methylation of RBM39 by PRMT6 enhances resistance to Indisulam in non-small cell lung cancer by promoting alternative splicing of proto-oncogenes

Tongjia Zhang; Shujie Wang; Yue Zhou; Zitao Jiao; Kejia Lu; Xinyi Liu; Hui Li; Wei Jiang; Xiaowei Zhang

doi:10.1371/journal.pbio.3002846

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Open Access

Peer-reviewed

Research Article

Methylation of RBM39 by PRMT6 enhances resistance to Indisulam in non-small cell lung cancer by promoting alternative splicing of proto-oncogenes

Tongjia Zhang,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Shujie Wang,

Roles Methodology

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Yue Zhou,

Roles Formal analysis

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Zitao Jiao,

Roles Methodology

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Kejia Lu,

Roles Data curation

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Xinyi Liu,

Roles Resources

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Hui Li,

Roles Methodology

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Wei Jiang,

Roles Validation

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China
⨯
Xiaowei Zhang

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: xiaoweizhang@bjmu.edu.cn

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing, China

https://orcid.org/0000-0001-7280-2844

⨯

Methylation of RBM39 by PRMT6 enhances resistance to Indisulam in non-small cell lung cancer by promoting alternative splicing of proto-oncogenes

Tongjia Zhang,
Shujie Wang,
Yue Zhou,
Zitao Jiao,
Kejia Lu,
Xinyi Liu,
Hui Li,
Wei Jiang,
Xiaowei Zhang

Published: June 4, 2025
https://doi.org/10.1371/journal.pbio.3002846

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Non-small cell lung cancer
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Methylation
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Immunoprecipitation
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Cancer treatment
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MTT assay
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Lung and intrathoracic tumors
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Transfection
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Ubiquitination
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