Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode

• Aijun Liu ,

  Contributed equally to this work with: Aijun Liu, Yezhou Liu, Geng Chen, Wenping Lyu

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China, Dongguan Songshan Lake Central Hospital, Dongguan Third People’s Hospital, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, China

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• Yezhou Liu ,

  Contributed equally to this work with: Aijun Liu, Yezhou Liu, Geng Chen, Wenping Lyu

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Geng Chen ,

  Contributed equally to this work with: Aijun Liu, Yezhou Liu, Geng Chen, Wenping Lyu

  Roles Data curation, Investigation

  Affiliation Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Wenping Lyu ,

  Contributed equally to this work with: Aijun Liu, Yezhou Liu, Geng Chen, Wenping Lyu

  Roles Data curation, Investigation, Methodology, Visualization

  Affiliation Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Fang Ye,

  Roles Investigation

  Affiliation Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Junlin Wang,

  Roles Investigation

  Affiliation Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Qiwen Liao,

  Roles Investigation

  Affiliation Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Lizhe Zhu ,

  Roles Supervision, Funding acquisition

  * E-mail: zhulizhe@cuhk.edu.cn (LZ); yangdu@cuhk.edu.cn (YD); richardye@cuhk.edu.cn (RDY)

  Affiliation Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Yang Du ,

  Roles Funding acquisition, Supervision

  * E-mail: zhulizhe@cuhk.edu.cn (LZ); yangdu@cuhk.edu.cn (YD); richardye@cuhk.edu.cn (RDY)

  Affiliation Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China

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• Richard D. Ye

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: zhulizhe@cuhk.edu.cn (LZ); yangdu@cuhk.edu.cn (YD); richardye@cuhk.edu.cn (RDY)

  Affiliations Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China, The Chinese University of Hong Kong, Shenzhen Futian Biomedical Innovation R&D Center, Shenzhen, China

  https://orcid.org/0000-0002-2164-5620

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