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Open Access
Peer-reviewed
Research Article
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation
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Gaowei Jin ,
Contributed equally to this work with: Gaowei Jin, Joaquín Campos, Yang Liu
Roles Data curation, Formal analysis, Investigation, Validation, Visualization
Affiliations Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, Southern University of Science and Technology, Shenzhen, China, Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Joaquín Campos ,
Contributed equally to this work with: Gaowei Jin, Joaquín Campos, Yang Liu
Roles Data curation, Formal analysis, Funding acquisition, Investigation, Validation
Affiliation Chica and Heinz Schaller Foundation, Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
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Yang Liu ,
Contributed equally to this work with: Gaowei Jin, Joaquín Campos, Yang Liu
Roles Data curation, Formal analysis, Investigation, Validation, Visualization
Affiliations Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, Southern University of Science and Technology, Shenzhen, China, Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Berta Marcó de la Cruz,
Roles Data curation, Formal analysis, Investigation
Affiliations Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
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Shujing Zhang,
Roles Formal analysis, Investigation
Affiliations Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Mingfu Liang,
Roles Formal analysis, Investigation
Affiliations Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Kaiyue Li,
Roles Formal analysis, Investigation
Affiliations Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Xingqiao Xie,
Roles Formal analysis, Funding acquisition, Resources
Affiliations Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, Southern University of Science and Technology, Shenzhen, China, Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Fredrik H. Sterky ,
Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Visualization, Writing – review & editing
* E-mail: fredrik.sterky@gu.se (FHS); acuna@uni-heidelberg.de (CA); weizy@sustech.edu.cn (ZW)
Affiliations Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden, Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
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Claudio Acuna ,
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: fredrik.sterky@gu.se (FHS); acuna@uni-heidelberg.de (CA); weizy@sustech.edu.cn (ZW)
Affiliation Chica and Heinz Schaller Foundation, Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
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Zhiyi Wei
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: fredrik.sterky@gu.se (FHS); acuna@uni-heidelberg.de (CA); weizy@sustech.edu.cn (ZW)
Affiliations Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, Southern University of Science and Technology, Shenzhen, China, Brain Research Center, Southern University of Science and Technology, Shenzhen, China, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China, Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, China
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The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation
- Gaowei Jin,
- Joaquín Campos,
- Yang Liu,
- Berta Marcó de la Cruz,
- Shujing Zhang,
- Mingfu Liang,
- Kaiyue Li,
- Xingqiao Xie,
- Fredrik H. Sterky,
- Claudio Acuna
- Published: June 10, 2025
- https://doi.org/10.1371/journal.pbio.3002817