The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

Aurélie Chazot; Claire Zimberger; Mikael Feracci; Adel Moussa; Steven Good; Jean-Pierre Sommadossi; Karine Alvarez; François Ferron; Bruno Canard

doi:10.1371/journal.pbio.3002743

Loading metrics

Open Access

Peer-reviewed

Short Reports offer exciting novel biological findings that may trigger new research directions.

See Journal Information »

The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

Aurélie Chazot,

Roles Formal analysis, Investigation

Affiliation Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France
⨯
Claire Zimberger,

Roles Formal analysis, Investigation

Affiliation Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France
⨯
Mikael Feracci,

Roles Formal analysis, Investigation

Affiliation Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France
⨯
Adel Moussa,

Roles Formal analysis, Investigation

Affiliation ATEA Pharmaceuticals, Inc., Boston, Massachusetts, United States of America
⨯
Steven Good,

Roles Formal analysis, Methodology

Affiliation ATEA Pharmaceuticals, Inc., Boston, Massachusetts, United States of America
⨯
Jean-Pierre Sommadossi,

Roles Project administration, Supervision

Affiliation ATEA Pharmaceuticals, Inc., Boston, Massachusetts, United States of America
⨯
Karine Alvarez,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France
⨯
François Ferron ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: francois.ferron@univ-amu.fr (FF); bruno.canard@univ-amu.fr (BC)

Affiliations Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France, European Virus Bioinformatics Center, Jena, Germany

https://orcid.org/0000-0002-8351-4992

⨯
Bruno Canard

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: francois.ferron@univ-amu.fr (FF); bruno.canard@univ-amu.fr (BC)

Affiliations Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France, European Virus Bioinformatics Center, Jena, Germany

https://orcid.org/0000-0003-4924-1991

⨯

The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

Aurélie Chazot,
Claire Zimberger,
Mikael Feracci,
Adel Moussa,
Steven Good,
Jean-Pierre Sommadossi,
Karine Alvarez,
François Ferron,
Bruno Canard

Published: August 27, 2024
https://doi.org/10.1371/journal.pbio.3002743

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Phosphates
Is the Subject Area "Phosphates" applicable to this article?

Thanks for your feedback.
Enzyme assays
Is the Subject Area "Enzyme assays" applicable to this article?

Thanks for your feedback.
Nucleosides
Is the Subject Area "Nucleosides" applicable to this article?

Thanks for your feedback.
Pro-drugs
Is the Subject Area "Pro-drugs" applicable to this article?

Thanks for your feedback.
Ribose
Is the Subject Area "Ribose" applicable to this article?

Thanks for your feedback.
Purines
Is the Subject Area "Purines" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.