Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits

• Jessica E. Buddle,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, United Kingdom

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• Lucy M. Thompson,

  Roles Investigation, Writing – review & editing

  Affiliation Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, United Kingdom

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• Anne S. Williams,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom

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• Rosanna C. T. Wright,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Division of Evolution and Genomic Sciences, University of Manchester, Manchester, United Kingdom

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• William M. Durham,

  Roles Formal analysis, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom

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• Claire E. Turner,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, United Kingdom

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• Roy R. Chaudhuri,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, United Kingdom

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• Michael A. Brockhurst ,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: michael.brockhurst@manchester.ac.uk (MAB); r.fagan@sheffield.ac.uk (RPF)

  Affiliation Division of Evolution and Genomic Sciences, University of Manchester, Manchester, United Kingdom

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• Robert P. Fagan

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: michael.brockhurst@manchester.ac.uk (MAB); r.fagan@sheffield.ac.uk (RPF)

  Affiliation Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, United Kingdom

  https://orcid.org/0000-0002-8704-4828

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