Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection

• Xin Yin ,

  Contributed equally to this work with: Xin Yin, Yuan Pu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  ⨯
• Yuan Pu ,

  Contributed equally to this work with: Xin Yin, Yuan Pu

  Roles Investigation, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Shuofeng Yuan,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China,

  ⨯
• Lars Pache,

  Roles Formal analysis, Visualization, Writing – review & editing

  Affiliation NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America

  ⨯
• Christopher Churas,

  Roles Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Stuart Weston,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Laura Riva,

  Roles Investigation, Writing – review & editing

  Affiliation Calibr-Skaggs at Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Lacy M. Simons,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• William J. Cisneros,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• Thomas Clausen,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America

  ⨯
• Grace Biddle,

  Roles Formal analysis, Investigation

  Affiliation Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Simon Doss-Gollin,

  Roles Formal analysis, Investigation

  Affiliation Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Meagan Deming,

  Roles Formal analysis, Investigation

  Affiliation Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Paul D. De Jesus,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Ha Na Kim,

  Roles Investigation, Writing – review & editing

  Affiliation Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia

  ⨯
• Daniel Fuentes,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• John M. Whitelock,

  Roles Investigation, Writing – review & editing

  Affiliation Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia

  ⨯
• Jeffrey D. Esko,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America

  ⨯
• Megan S. Lord,

  Roles Supervision, Writing – review & editing

  Affiliation Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia

  ⨯
• Ignacio Mena,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Adolfo García-Sastre,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Tisch Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Judd F. Hultquist,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• Matthew B. Frieman,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Trey Ideker,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Dexter Pratt,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Laura Martin-Sancho ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: laura.martin-sancho@imperial.ac.uk (LM-S); schanda@scripps.edu (SKC)

  ¶These authors are senior authors on this work.

  Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0003-1489-2815

  ⨯
•  [ ... ],
• Sumit K. Chanda

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: laura.martin-sancho@imperial.ac.uk (LM-S); schanda@scripps.edu (SKC)

  ¶These authors are senior authors on this work.

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Calibr-Skaggs at Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• [ view all ]
• [ view less ]