Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis

• Heejin Jun ,

  Contributed equally to this work with: Heejin Jun, Shanshan Liu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: hejun@ttu.edu (HJ); wujunz@umich.edu (JW)

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, Texas, United States of America

  ⨯
• Shanshan Liu ,

  Contributed equally to this work with: Heejin Jun, Shanshan Liu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Alexander J. Knights,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Kezhou Zhu,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Yingxu Ma,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, China

  ⨯
• Jianke Gong,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Sciences and Technology, and Huazhong University of Science and Technology, Wuhan, China

  ⨯
• Ashley E. Lenhart,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Xiaoling Peng,

  Roles Data curation, Investigation

  Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Yunying Huang,

  Roles Data curation, Investigation

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, China

  ⨯
• Jared P. Ginder,

  Roles Data curation, Investigation

  Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Christopher H. Downie,

  Roles Data curation, Investigation

  Affiliation Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Erika Thalia Ramos,

  Roles Investigation

  Affiliation Department of Nutritional Sciences, College of Human Sciences, Texas Tech University, Lubbock, Texas, United States of America

  ⨯
• Klas Kullander,

  Roles Methodology

  Affiliation Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

  ⨯
• Robert T. Kennedy,

  Roles Formal analysis, Funding acquisition, Methodology

  Affiliations Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• X. Z. Shawn Xu,

  Roles Formal analysis, Funding acquisition, Methodology

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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•  [ ... ],
• Jun Wu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hejun@ttu.edu (HJ); wujunz@umich.edu (JW)

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0003-4493-5820

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