Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

• Weichen Zhou ,

  Contributed equally to this work with: Weichen Zhou, Kalpita R. Karan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Kalpita R. Karan ,

  Contributed equally to this work with: Weichen Zhou, Kalpita R. Karan

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

  ⨯
• Wenjin Gu,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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• Hans-Ulrich Klein,

  Roles Data curation, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

  Affiliations Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, United States of America, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America

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• Gabriel Sturm,

  Roles Data curation, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

  Affiliations Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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• Philip L. De Jager,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, United States of America, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America

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• David A. Bennett,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

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• Michio Hirano,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Martin Picard ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: martin.picard@columbia.edu (MP); remills@umich.edu (REM)

  Affiliations Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Neurology, H. Houston Merritt Center, Columbia University Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, New York, United States of America, New York State Psychiatric Institute, New York, New York, United States of America, Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, New York, United States of America

  https://orcid.org/0000-0003-2835-0478

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• Ryan E. Mills

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: martin.picard@columbia.edu (MP); remills@umich.edu (REM)

  Affiliations Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0003-3425-6998

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