KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice

Zhong Ding; Chunsheng Zhang; Huicui Yang; Jiaojiao Chen; Zhiruo Sun; Xuechu Zhen

doi:10.1371/journal.pbio.3002716

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Open Access

Peer-reviewed

Research Article

KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice

Zhong Ding ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

* E-mail: dingz@suda.edu.cn (ZD); zhenxuechu@suda.edu.cn (XZ)

Affiliation Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China

https://orcid.org/0009-0000-1111-2727

⨯
Chunsheng Zhang,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software

Affiliation Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China
⨯
Huicui Yang,

Roles Data curation, Methodology, Resources, Software, Validation

Affiliation Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China
⨯
Jiaojiao Chen,

Roles Data curation, Investigation, Methodology, Resources, Software

Affiliation Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China
⨯
Zhiruo Sun,

Roles Data curation, Investigation, Methodology, Resources, Software

Affiliation Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China
⨯
Xuechu Zhen

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – review & editing

* E-mail: dingz@suda.edu.cn (ZD); zhenxuechu@suda.edu.cn (XZ)

Affiliation Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China
⨯

KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice

Zhong Ding,
Chunsheng Zhang,
Huicui Yang,
Jiaojiao Chen,
Zhiruo Sun,
Xuechu Zhen

Published: July 15, 2024
https://doi.org/10.1371/journal.pbio.3002716

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Morphine
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Transfection
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Sensory perception
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Adenylyl cyclase
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