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Open Access
Peer-reviewed
Research Article
Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects
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Yevgeniy Plavskin,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliations Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Department of Biology, New York University, New York, New York, United States of America
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Maria Stella de Biase,
Roles Investigation, Writing – review & editing
Affiliations Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Humboldt-Universität zu Berlin, Department of Biology, Berlin, Germany
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Naomi Ziv,
Roles Investigation, Writing – review & editing
Current address: Shmunis School of Biomedical and Cancer Research, Tel Aviv University, Ramat Aviv, Israel
Affiliations Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Department of Biology, New York University, New York, New York, United States of America
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Libuše Janská,
Roles Investigation, Writing – review & editing
Affiliations Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Department of Biology, New York University, New York, New York, United States of America
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Yuan O. Zhu,
Roles Investigation, Writing – review & editing
Affiliations Department of Genetics, Stanford University, Stanford, California, United States of America, Department of Biology, Stanford University, Stanford, California, United States of America
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David W. Hall,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Genetics, University of Georgia, Athens, Georgia, United States of America
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Roland F. Schwarz,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliations Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Institute for Computational Cancer Biology, Center for Integrated Oncology (CIO), Cancer Research Center Cologne Essen (CCCE), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, Berlin Institute for the Foundations of Learning and Data (BIFOLD), Berlin, Germany
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Daniel Tranchina,
Roles Conceptualization, Methodology, Software, Supervision, Writing – review & editing
Affiliations Department of Biology, New York University, New York, New York, United States of America, Courant Math Institute, New York University, New York, New York, United States of America
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Mark L. Siegal
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – review & editing
* E-mail: mark.siegal@nyu.edu
Affiliations Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Department of Biology, New York University, New York, New York, United States of America
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Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects
- Yevgeniy Plavskin,
- Maria Stella de Biase,
- Naomi Ziv,
- Libuše Janská,
- Yuan O. Zhu,
- David W. Hall,
- Roland F. Schwarz,
- Daniel Tranchina,
- Mark L. Siegal
![PLOS](/resource/img/logo-plos.png)
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- Published: July 1, 2024
- https://doi.org/10.1371/journal.pbio.3002698