Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

• Kaleeckal G. Harikumar ,

  Contributed equally to this work with: Kaleeckal G. Harikumar, Peishen Zhao, Brian P. Cary

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America

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• Peishen Zhao ,

  Contributed equally to this work with: Kaleeckal G. Harikumar, Peishen Zhao, Brian P. Cary

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Brian P. Cary ,

  Contributed equally to this work with: Kaleeckal G. Harikumar, Peishen Zhao, Brian P. Cary

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Xiaomeng Xu,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Aditya J. Desai,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America

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• Maoqing Dong,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America

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• Jesse I. Mobbs,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Chirine Toufaily,

  Roles Writing – review & editing

  Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America

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• Sebastian G. B. Furness,

  Roles Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, School of Biomedical Sciences, University Queensland, Queensland, Australia

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• Arthur Christopoulos,

  Roles Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Matthew J. Belousoff,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Denise Wootten ,

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft

  * E-mail: denise.wootten@monash.edu (DW); patrick.sexton@monash.edu (PMS); miller@mayo.edu (LJM)

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

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• Patrick M. Sexton ,

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft

  * E-mail: denise.wootten@monash.edu (DW); patrick.sexton@monash.edu (PMS); miller@mayo.edu (LJM)

  Affiliations Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia

  ⨯
• Laurence J. Miller

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: denise.wootten@monash.edu (DW); patrick.sexton@monash.edu (PMS); miller@mayo.edu (LJM)

  Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America

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