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Open Access
Peer-reviewed
Research Article
KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation
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Xiangchan Hou,
Roles Data curation, Writing – original draft
Affiliations NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Jiawei Ouyang,
Roles Data curation
Affiliation Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Le Tang,
Roles Data curation
Affiliation Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Pan Wu,
Roles Data curation
Affiliation Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Xiangying Deng,
Roles Data curation
Affiliation Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Qijia Yan,
Roles Data curation
Affiliation Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China
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Lei Shi ,
Roles Conceptualization
* E-mail: shilei81@csu.edu.cn (LS); zengzhaoyang@csu.edu.cn (ZZ); wfy4010@csu.edu.cn (FW)
Affiliation Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China
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Songqing Fan,
Roles Data curation
Affiliation Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China
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Chunmei Fan,
Roles Data curation
Affiliation Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Can Guo,
Roles Writing – review & editing
Affiliation Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Qianjin Liao,
Roles Writing – review & editing
Affiliation NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Yong Li,
Roles Data curation
Affiliation Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
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Wei Xiong,
Roles Writing – review & editing
Affiliations NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Guiyuan Li,
Roles Data curation
Affiliations NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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Zhaoyang Zeng ,
Roles Conceptualization, Writing – original draft, Writing – review & editing
* E-mail: shilei81@csu.edu.cn (LS); zengzhaoyang@csu.edu.cn (ZZ); wfy4010@csu.edu.cn (FW)
Affiliations NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
⨯ - [ ... ],
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Fuyan Wang
Roles Conceptualization, Writing – original draft, Writing – review & editing
* E-mail: shilei81@csu.edu.cn (LS); zengzhaoyang@csu.edu.cn (ZZ); wfy4010@csu.edu.cn (FW)
Affiliations NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China
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KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation
- Xiangchan Hou,
- Jiawei Ouyang,
- Le Tang,
- Pan Wu,
- Xiangying Deng,
- Qijia Yan,
- Lei Shi,
- Songqing Fan,
- Chunmei Fan,
- Can Guo
![PLOS](/resource/img/logo-plos.png)
- Published: June 21, 2024
- https://doi.org/10.1371/journal.pbio.3002666