Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior

• Sarfraz Shafiq,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Canada, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

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• Alireza Ghahramani ,

  Contributed equally to this work with: Alireza Ghahramani, Kasha Mansour, Miguel Pena-Ortiz

  Roles Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliations Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Canada, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

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• Kasha Mansour ,

  Contributed equally to this work with: Alireza Ghahramani, Kasha Mansour, Miguel Pena-Ortiz

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Canada, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

  ⨯
• Miguel Pena-Ortiz ,

  Contributed equally to this work with: Alireza Ghahramani, Kasha Mansour, Miguel Pena-Ortiz

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

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• Julia K. Sunstrum,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Graduate Program in Neuroscience, Western University, London, Canada, Robarts Research Institute, Western University, London, Canada

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• Milica Pavlovic,

  Roles Data curation, Formal analysis, Methodology, Visualization

  Affiliations Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Canada, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

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• Yan Jiang,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

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• Megan E. Rowland,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada

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• Wataru Inoue,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliations Graduate Program in Neuroscience, Western University, London, Canada, Robarts Research Institute, Western University, London, Canada

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• Nathalie G. Bérubé

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: nberube@uwo.ca

  Affiliations Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Canada, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, Canada, Division of Genetics & Development, Children’s Health Research Institute, London, Canada, Graduate Program in Neuroscience, Western University, London, Canada

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