SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability

Maïlyn Yates; Isabelle Marois; Edlie St-Hilaire; Daryl A. Ronato; Billel Djerir; Chloé Brochu; Théo Morin; Ian Hammond-Martel; Sari Gezzar-Dandashi; Lisa Casimir; Elliot Drobetsky; Laurent Cappadocia; Jean-Yves Masson; Hugo Wurtele; Alexandre Maréchal

doi:10.1371/journal.pbio.3002552

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Open Access

Peer-reviewed

Research Article

SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability

Maïlyn Yates,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada
⨯
Isabelle Marois,

Roles Data curation, Investigation, Writing – review & editing

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada
⨯
Edlie St-Hilaire ,

Contributed equally to this work with: Edlie St-Hilaire, Daryl A. Ronato, Sari Gezzar-Dandashi

Roles Investigation

Affiliation Research Center, Maisonneuve-Rosemont Hospital, Montréal, Canada
⨯
Daryl A. Ronato ,

Contributed equally to this work with: Edlie St-Hilaire, Daryl A. Ronato, Sari Gezzar-Dandashi

Roles Investigation, Resources, Writing – review & editing

Affiliation Genome Stability Laboratory, CHU de Québec Research Center, Oncology Division; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Québec City, Canada
⨯
Billel Djerir,

Roles Investigation

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada
⨯
Chloé Brochu,

Roles Investigation

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada
⨯
Théo Morin,

Roles Investigation

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada
⨯
Ian Hammond-Martel,

Roles Investigation, Writing – review & editing

Affiliation Research Center, Maisonneuve-Rosemont Hospital, Montréal, Canada
⨯
Sari Gezzar-Dandashi ,

Contributed equally to this work with: Edlie St-Hilaire, Daryl A. Ronato, Sari Gezzar-Dandashi

Roles Investigation

Affiliation Research Center, Maisonneuve-Rosemont Hospital, Montréal, Canada
⨯
Lisa Casimir,

Roles Investigation

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada
⨯
Elliot Drobetsky,

Roles Funding acquisition, Supervision

Affiliations Research Center, Maisonneuve-Rosemont Hospital, Montréal, Canada, Medicine Department, Université de Montréal, Montréal, Canada
⨯
Laurent Cappadocia,

Roles Formal analysis, Funding acquisition, Investigation, Visualization, Writing – review & editing

Affiliation Faculty of Sciences, Department of Chemistry, Université du Québec à Montréal, Montréal, Canada
⨯
Jean-Yves Masson,

Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Genome Stability Laboratory, CHU de Québec Research Center, Oncology Division; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Québec City, Canada
⨯
Hugo Wurtele,

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

Affiliations Research Center, Maisonneuve-Rosemont Hospital, Montréal, Canada, Medicine Department, Université de Montréal, Montréal, Canada
⨯
Alexandre Maréchal

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: alexandre.marechal@usherbrooke.ca

Affiliations Faculty of Sciences, Department of Biology, Université de Sherbrooke, Sherbrooke, Canada, CHUS Research Center and Cancer Research Institute, Sherbrooke, Canada

https://orcid.org/0000-0003-3216-6542

⨯

SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability

Maïlyn Yates,
Isabelle Marois,
Edlie St-Hilaire,
Daryl A. Ronato,
Billel Djerir,
Chloé Brochu,
Théo Morin,
Ian Hammond-Martel,
Sari Gezzar-Dandashi,
Lisa Casimir

Published: March 19, 2024
https://doi.org/10.1371/journal.pbio.3002552

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