Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4^DCAF11 E3 ubiquitin ligase complex for targeted protein degradation

• Ying Wang ,

  Contributed equally to this work with: Ying Wang, Tianzi Wei, Man Zhao

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China

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• Tianzi Wei ,

  Contributed equally to this work with: Ying Wang, Tianzi Wei, Man Zhao

  Roles Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key University Laboratory of Metabolism and Health of Guangdong, Department of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China

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• Man Zhao ,

  Contributed equally to this work with: Ying Wang, Tianzi Wei, Man Zhao

  Roles Data curation, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China

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• Aima Huang,

  Roles Data curation, Methodology, Project administration, Visualization

  Affiliation Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

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• Fan Sun,

  Roles Data curation, Methodology, Project administration, Validation, Visualization

  Affiliation Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

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• Lu Chen,

  Roles Data curation, Methodology, Project administration, Validation, Visualization

  Affiliation School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China

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• Risheng Lin,

  Roles Data curation, Methodology, Project administration, Visualization

  Affiliation Key University Laboratory of Metabolism and Health of Guangdong, Department of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China

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• Yubao Xie,

  Roles Methodology, Project administration, Visualization

  Affiliation School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China

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• Ming Zhang,

  Roles Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization

  Affiliation School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China

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• Shiyu Xu,

  Roles Data curation, Project administration, Visualization

  Affiliation Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

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• Zhihui Sun,

  Roles Data curation, Project administration, Visualization

  Affiliation Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

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• Liang Hong ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Software, Supervision, Writing – review & editing

  * E-mail: hongliang@sysu.edu.cn (LH); wangrui@lzu.edu.cn (RW); tianrl@sustech.edu.cn (RT); liguofeng@szu.edu.cn (GL)

  Affiliation Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

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• Rui Wang ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Software, Supervision, Writing – review & editing

  * E-mail: hongliang@sysu.edu.cn (LH); wangrui@lzu.edu.cn (RW); tianrl@sustech.edu.cn (RT); liguofeng@szu.edu.cn (GL)

  Affiliations School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China, Institute of Materia Medica and Research Unit of Peptide Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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• Ruilin Tian ,

  Roles Data curation, Formal analysis, Funding acquisition, Resources, Software, Supervision, Validation, Writing – review & editing

  * E-mail: hongliang@sysu.edu.cn (LH); wangrui@lzu.edu.cn (RW); tianrl@sustech.edu.cn (RT); liguofeng@szu.edu.cn (GL)

  Affiliation Key University Laboratory of Metabolism and Health of Guangdong, Department of Medical Neuroscience, School of Medicine, Southern University of Science and Technology, Shenzhen, China

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• Guofeng Li

  Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Writing – review & editing

  * E-mail: hongliang@sysu.edu.cn (LH); wangrui@lzu.edu.cn (RW); tianrl@sustech.edu.cn (RT); liguofeng@szu.edu.cn (GL)

  Affiliation School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China

  https://orcid.org/0000-0002-7528-2036

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