A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide

Lujie Liang; Lan-Lan Zhong; Lin Wang; Dianrong Zhou; Yaxin Li; Jiachen Li; Yong Chen; Wanfei Liang; Wenjing Wei; Chenchen Zhang; Hui Zhao; Lingxuan Lyu; Nicole Stoesser; Yohei Doi; Fang Bai; Siyuan Feng; Guo-Bao Tian

doi:10.1371/journal.pbio.3002433

Loading metrics

Open Access

Peer-reviewed

Research Article

A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide

Lujie Liang ,

Contributed equally to this work with: Lujie Liang, Lan-Lan Zhong, Lin Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Lan-Lan Zhong ,

Contributed equally to this work with: Lujie Liang, Lan-Lan Zhong, Lin Wang

Roles Resources

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Lin Wang ,

Contributed equally to this work with: Lujie Liang, Lan-Lan Zhong, Lin Wang

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Software, Visualization

Affiliation Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University, Shanghai, China
⨯
Dianrong Zhou,

Roles Conceptualization, Investigation, Methodology

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Yaxin Li,

Roles Investigation, Methodology

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Jiachen Li,

Roles Formal analysis

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Yong Chen,

Roles Investigation, Methodology

Affiliation School of Laboratory Medicine, Chengdu Medical College, Chengdu, China
⨯
Wanfei Liang,

Roles Investigation, Methodology

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Wenjing Wei,

Roles Investigation, Methodology

Affiliation Center for Tuberculosis Control of Guangdong Province, Guangzhou, Guangdong, China
⨯
Chenchen Zhang,

Roles Investigation, Methodology

Affiliation Center for Tuberculosis Control of Guangdong Province, Guangzhou, Guangdong, China
⨯
Hui Zhao,

Roles Resources

Affiliation Laboratory Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Lingxuan Lyu,

Roles Investigation, Methodology

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
Nicole Stoesser,

Roles Conceptualization

Affiliation Modernising Medical Microbiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⨯
Yohei Doi,

Roles Conceptualization

Affiliations University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology, Fujita Health University School of Medicine, Aichi, Japan
⨯
Fang Bai ,

Roles Conceptualization

* E-mail: baifang@shanghaitech.edu.cn (FB); fsy0593@163.com (SF); tiangb@mail.sysu.edu.cn (G-BT)

Affiliation Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University, Shanghai, China

https://orcid.org/0000-0003-1468-5568

⨯
Siyuan Feng ,

Roles Funding acquisition

* E-mail: baifang@shanghaitech.edu.cn (FB); fsy0593@163.com (SF); tiangb@mail.sysu.edu.cn (G-BT)

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯
[ ... ],
Guo-Bao Tian

Roles Conceptualization, Funding acquisition

* E-mail: baifang@shanghaitech.edu.cn (FB); fsy0593@163.com (SF); tiangb@mail.sysu.edu.cn (G-BT)

Affiliations Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Department of Immunology, School of Medicine, Sun Yat-Sen University, Shenzhen, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China

https://orcid.org/0000-0001-6750-5482

⨯
[ view all ]
[ view less ]

A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide

Lujie Liang,
Lan-Lan Zhong,
Lin Wang,
Dianrong Zhou,
Yaxin Li,
Jiachen Li,
Yong Chen,
Wanfei Liang,
Wenjing Wei,
Chenchen Zhang

Published: December 13, 2023
https://doi.org/10.1371/journal.pbio.3002433

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Escherichia coli
Is the Subject Area "Escherichia coli" applicable to this article?

Thanks for your feedback.
Antibiotics
Is the Subject Area "Antibiotics" applicable to this article?

Thanks for your feedback.
Permeability
Is the Subject Area "Permeability" applicable to this article?

Thanks for your feedback.
Membrane potential
Is the Subject Area "Membrane potential" applicable to this article?

Thanks for your feedback.
Antibiotic resistance
Is the Subject Area "Antibiotic resistance" applicable to this article?

Thanks for your feedback.
Antimicrobials
Is the Subject Area "Antimicrobials" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.