The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism

Mona Nazemi; Bian Yanes; Montserrat Llanses Martinez; Heather J. Walker; Khoa Pham; Mark O. Collins; Frederic Bard; Elena Rainero

doi:10.1371/journal.pbio.3002406

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Open Access

Peer-reviewed

Research Article

The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism

Mona Nazemi,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation School of Biosciences, The University of Sheffield, Sheffield, United Kingdom
⨯
Bian Yanes ,

Contributed equally to this work with: Bian Yanes, Montserrat Llanses Martinez

Roles Formal analysis, Investigation

Affiliation School of Biosciences, The University of Sheffield, Sheffield, United Kingdom
⨯
Montserrat Llanses Martinez ,

Contributed equally to this work with: Bian Yanes, Montserrat Llanses Martinez

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliations School of Biosciences, The University of Sheffield, Sheffield, United Kingdom, Institute of Molecular and Cell Biology, Singapore
⨯
Heather J. Walker,

Roles Investigation

Affiliation biOMICS Facility, School of Biosciences, The University of Sheffield, Sheffield, United Kingdom
⨯
Khoa Pham,

Roles Formal analysis, Investigation

Affiliation biOMICS Facility, School of Biosciences, The University of Sheffield, Sheffield, United Kingdom
⨯
Mark O. Collins,

Roles Conceptualization, Funding acquisition, Supervision

Affiliations School of Biosciences, The University of Sheffield, Sheffield, United Kingdom, biOMICS Facility, School of Biosciences, The University of Sheffield, Sheffield, United Kingdom
⨯
Frederic Bard,

Roles Funding acquisition, Supervision

Affiliations Institute of Molecular and Cell Biology, Singapore, Centre de Recherche en Cancerologie de Marseille, CRCM, Marseille, France
⨯
Elena Rainero

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: e.rainero@sheffield.ac.uk

Affiliation School of Biosciences, The University of Sheffield, Sheffield, United Kingdom

https://orcid.org/0000-0003-1402-8701

⨯

The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism

Mona Nazemi,
Bian Yanes,
Montserrat Llanses Martinez,
Heather J. Walker,
Khoa Pham,
Mark O. Collins,
Frederic Bard,
Elena Rainero

Published: January 16, 2024
https://doi.org/10.1371/journal.pbio.3002406

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