Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

• Spyros Lytras ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: spyros.lytras@glasgow.ac.uk (SL); sjw58@cam.ac.uk (SJW)

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

  https://orcid.org/0000-0003-4202-6682

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• Arthur Wickenhagen ,

  Contributed equally to this work with: Arthur Wickenhagen, Elena Sugrue

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Elena Sugrue ,

  Contributed equally to this work with: Arthur Wickenhagen, Elena Sugrue

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Douglas G. Stewart,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Simon Swingler,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Anna Sims,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Hollie Jackson Ireland,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Emma L. Davies,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Eliza M. Ludlam,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Zhuonan Li,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Joseph Hughes,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

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• Sam J. Wilson

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: spyros.lytras@glasgow.ac.uk (SL); sjw58@cam.ac.uk (SJW)

  Affiliations MRC–University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0002-6065-0895

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