Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth

• Aina He ,

  Contributed equally to this work with: Aina He, Songhai Tian

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft

  Affiliations Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

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• Songhai Tian ,

  Contributed equally to this work with: Aina He, Songhai Tian

  Roles Conceptualization, Data curation, Formal analysis, Investigation

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China

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• Oded Kopper,

  Roles Investigation

  Affiliation Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands

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• Daniel J. Horan,

  Roles Investigation

  Affiliation Department of Anatomy & Cell Biology, Indiana University School of Medicine, Barnhill, Indianapolis, United States of America

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• Peng Chen,

  Roles Investigation

  Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America

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• Roderick T. Bronson,

  Roles Investigation

  Affiliation Rodent Histopathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ren Sheng,

  Roles Investigation

  Affiliation Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Hao Wu,

  Roles Investigation

  Affiliation Department of Vascular Biology, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Lufei Sui,

  Roles Investigation

  Affiliation Department of Vascular Biology, Boston Children’s Hospital, Boston, Massachusetts, United States of America

  ⨯
• Kun Zhou,

  Roles Investigation

  Affiliation Department of Vascular Biology, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Liang Tao,

  Roles Investigation

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

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• Quan Wu,

  Roles Investigation

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, Central Laboratory of Medical Research Centre, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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• Yujing Huang,

  Roles Investigation

  Affiliation Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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• Zan Shen,

  Roles Investigation

  Affiliation Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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• Sen Han,

  Roles Investigation

  Affiliations Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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• Xueqing Chen,

  Roles Investigation

  Affiliations Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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• Hong Chen,

  Roles Investigation

  Affiliation Department of Vascular Biology, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Xi He,

  Roles Investigation

  Affiliation Kirby Neurobiology Center, Boston Children’s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Alexander G. Robling,

  Roles Investigation

  Affiliation Department of Anatomy & Cell Biology, Indiana University School of Medicine, Barnhill, Indianapolis, United States of America

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• Rongsheng Jin,

  Roles Conceptualization, Investigation

  Affiliation Department of Physiology and Biophysics, University of California, Irvine, California, United States of America

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• Hans Clevers,

  Roles Investigation

  Affiliation Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands

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• Dongxi Xiang ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

  * E-mail: dxiang@shsmu.edu.cn (DX); zli4@rics.bwh.harvard.edu (ZL); min.dong@childrens.harvard.edu (MD)

  Affiliations Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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• Zhe Li ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Writing – original draft

  * E-mail: dxiang@shsmu.edu.cn (DX); zli4@rics.bwh.harvard.edu (ZL); min.dong@childrens.harvard.edu (MD)

  Affiliations Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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•  [ ... ],
• Min Dong

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Writing – original draft

  * E-mail: dxiang@shsmu.edu.cn (DX); zli4@rics.bwh.harvard.edu (ZL); min.dong@childrens.harvard.edu (MD)

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-1744-7293

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