Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1

• Alexandre Pierga,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Sorbonne Université, Paris, France, Paris Brain Institute, ICM, Paris, France, Inserm, U1127, Paris, France, CNRS, UMR 7225, Paris, France

  ⨯
• Raphaël Matusiak,

  Roles Methodology, Software, Writing – original draft

  Affiliations Sorbonne Université, Paris, France, Paris Brain Institute, ICM, Paris, France, Inserm, U1127, Paris, France, CNRS, UMR 7225, Paris, France

  ⨯
• Margaux Cauhapé,

  Roles Investigation

  Affiliations Sorbonne Université, Paris, France, Paris Brain Institute, ICM, Paris, France, Inserm, U1127, Paris, France, CNRS, UMR 7225, Paris, France

  ⨯
• Julien Branchu,

  Roles Conceptualization, Formal analysis, Investigation

  Affiliations Sorbonne Université, Paris, France, Paris Brain Institute, ICM, Paris, France, Inserm, U1127, Paris, France, CNRS, UMR 7225, Paris, France

  ⨯
• Lydia Danglot,

  Roles Formal analysis

  Affiliations Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Membrane Traffic in Healthy and Diseased Brain, Université Paris Cité, Paris, France, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Scientific director of NeurImag facility, Université Paris Cité, Paris, France

  ⨯
• Maxime Boutry,

  Roles Conceptualization, Formal analysis, Investigation

  Affiliations Sorbonne Université, Paris, France, Paris Brain Institute, ICM, Paris, France, Inserm, U1127, Paris, France, CNRS, UMR 7225, Paris, France

  ⨯
• Frédéric Darios

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: frederic.darios@upmc.fr, frederic.darios@icm-institute.org

  Affiliations Sorbonne Université, Paris, France, Paris Brain Institute, ICM, Paris, France, Inserm, U1127, Paris, France, CNRS, UMR 7225, Paris, France

  https://orcid.org/0000-0001-9800-5990

  ⨯