Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling

• Elizabeth Padilla-Banks ,

  Contributed equally to this work with: Elizabeth Padilla-Banks, Wendy N. Jefferson, Brian N. Papas

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Wendy N. Jefferson ,

  Contributed equally to this work with: Elizabeth Padilla-Banks, Wendy N. Jefferson, Brian N. Papas

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Brian N. Papas ,

  Contributed equally to this work with: Elizabeth Padilla-Banks, Wendy N. Jefferson, Brian N. Papas

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Integrative Bioinformatics, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Alisa A. Suen,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Xin Xu,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Diana V. Carreon,

  Roles Investigation, Writing – review & editing

  Affiliation Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Cynthia J. Willson,

  Roles Investigation, Writing – review & editing

  Affiliation Inotiv-RTP, Research Triangle Park, North Carolina, United States of America

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• Erin M. Quist,

  Roles Investigation, Writing – review & editing

  Current address: Charles River Laboratories, Durham, North Carolina, United States of America

  Affiliation Experimental Pathology Laboratories, Research Triangle Park, North Carolina, United States of America

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• Carmen J. Williams

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: williamsc5@niehs.nih.gov

  Affiliation Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0001-6440-7086

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