The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs

• Danielle C. Hamm ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: dhamm@fredhutch.org (DCH); stapscot@fredhutch.org (SJT)

  Affiliation Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America

  https://orcid.org/0000-0003-2966-7389

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• Ellen M. Paatela,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliations Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington State, United States of America

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• Sean R. Bennett,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America

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• Chao-Jen Wong,

  Roles Data curation, Formal analysis, Methodology, Visualization

  Affiliation Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America

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• Amy E. Campbell,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

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• Cynthia L. Wladyka,

  Roles Investigation

  Affiliation Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America

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• Andrew A. Smith,

  Roles Methodology

  Affiliations Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington State, United States of America

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• Sujatha Jagannathan,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

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• Andrew C. Hsieh,

  Roles Funding acquisition, Methodology, Writing – review & editing

  Affiliations Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America, Departments of Medicine and Genome Sciences, University of Washington, Seattle, Washington State, United States of America

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• Stephen J. Tapscott

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dhamm@fredhutch.org (DCH); stapscot@fredhutch.org (SJT)

  Affiliations Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America, Department of Neurology, University of Washington, Seattle, Washington State, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington State, United States of America

  https://orcid.org/0000-0002-0319-0968

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