Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA

Yiqun Yang; Yuwan Liu; Haodong Zhao; Dingyu Liu; Jie Zhang; Jian Cheng; Qiaoyu Yang; Huanyu Chu; Xiaoyun Lu; Mengting Luo; Xiang Sheng; Yi-Heng P. J. Zhang; Huifeng Jiang; Yanhe Ma

doi:10.1371/journal.pbio.3002285

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Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA

Yiqun Yang ,

Contributed equally to this work with: Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu

Roles Data curation, Formal analysis, Investigation

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Yuwan Liu ,

Contributed equally to this work with: Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China, Haihe Laboratory of Synthetic Biology, Tianjin, China
⨯
Haodong Zhao ,

Contributed equally to this work with: Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu

Roles Formal analysis

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
⨯
Dingyu Liu ,

Contributed equally to this work with: Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu

Roles Formal analysis

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Jie Zhang,

Roles Investigation, Methodology

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
⨯
Jian Cheng,

Roles Methodology

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Qiaoyu Yang,

Roles Investigation

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Huanyu Chu,

Roles Formal analysis

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Xiaoyun Lu,

Roles Formal analysis, Funding acquisition

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Mengting Luo,

Roles Investigation

Affiliation School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, China
⨯
Xiang Sheng,

Roles Investigation, Software

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Yi-Heng P. J. Zhang,

Roles Investigation

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯
Huifeng Jiang ,

Roles Project administration, Supervision, Writing – review & editing

* E-mail: jiang_hf@tib.cas.cn (HJ); ma_yh@tib.cas.cn (YM)

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China, Haihe Laboratory of Synthetic Biology, Tianjin, China

https://orcid.org/0000-0002-3757-7896

⨯
Yanhe Ma

Roles Supervision, Writing – review & editing

* E-mail: jiang_hf@tib.cas.cn (HJ); ma_yh@tib.cas.cn (YM)

Affiliations Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, National Center of Technology Innovation for Synthetic Biology, Tianjin, China
⨯

Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA

Yiqun Yang,
Yuwan Liu,
Haodong Zhao,
Dingyu Liu,
Jie Zhang,
Jian Cheng,
Qiaoyu Yang,
Huanyu Chu,
Xiaoyun Lu,
Mengting Luo

Published: September 21, 2023
https://doi.org/10.1371/journal.pbio.3002285

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