A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans

• Raimund Jung,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany

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• Marie C. Lechler,

  Roles Investigation, Methodology, Writing – original draft

  Affiliations German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany, Graduate Training Centre of Neuroscience, International Max Planck Research School, Tübingen, Germany

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• Ana Fernandez-Villegas,

  Roles Investigation, Methodology, Validation

  Affiliation Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

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• Chyi Wei Chung,

  Roles Formal analysis, Investigation, Methodology

  Current address: Kavli Nanoscience Institute for Nanoscience Discovery, Department of Physics, University of Oxford, Oxford, United Kingdom

  Affiliation Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

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• Harry C. Jones,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation The Babraham Institute, Signalling Program, Cambridge, United Kingdom

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• Yoon Hee Choi,

  Roles Investigation, Methodology, Visualization

  Affiliation The Babraham Institute, Signalling Program, Cambridge, United Kingdom

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• Maximilian A. Thompson,

  Roles Formal analysis, Investigation, Methodology

  Affiliation The Babraham Institute, Signalling Program, Cambridge, United Kingdom

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• Christian Rödelsperger,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Max Planck Institute for Developmental Biology, Department for Integrative Evolutionary Biology, Tübingen, Germany

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• Waltraud Röseler,

  Roles Investigation, Methodology

  Affiliation Max Planck Institute for Developmental Biology, Department for Integrative Evolutionary Biology, Tübingen, Germany

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• Gabriele S. Kaminski Schierle,

  Roles Formal analysis, Funding acquisition, Supervision

  Affiliation Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

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• Ralf J. Sommer,

  Roles Funding acquisition, Supervision, Writing – original draft

  Affiliation Max Planck Institute for Developmental Biology, Department for Integrative Evolutionary Biology, Tübingen, Germany

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• Della C. David

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: della.david@babraham.ac.uk

  Affiliations German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany, The Babraham Institute, Signalling Program, Cambridge, United Kingdom, Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

  https://orcid.org/0000-0001-8597-9470

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