A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance

• Jiaojiao Hao ,

  Contributed equally to this work with: Jiaojiao Hao, Jinsheng Huang, Chunyu Hua, Yan Zuo

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Jinsheng Huang ,

  Contributed equally to this work with: Jiaojiao Hao, Jinsheng Huang, Chunyu Hua, Yan Zuo

  Roles Conceptualization, Investigation, Methodology

  Affiliation Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China

  ⨯
• Chunyu Hua ,

  Contributed equally to this work with: Jiaojiao Hao, Jinsheng Huang, Chunyu Hua, Yan Zuo

  Roles Conceptualization

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Yan Zuo ,

  Contributed equally to this work with: Jiaojiao Hao, Jinsheng Huang, Chunyu Hua, Yan Zuo

  Roles Data curation

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Wendan Yu,

  Roles Conceptualization, Investigation

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Xiaojun Wu,

  Roles Conceptualization

  Affiliation Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China

  ⨯
• Liren Li,

  Roles Formal analysis

  Affiliation Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China

  ⨯
• Guoqing Xue,

  Roles Resources, Supervision

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Xinyu Wan,

  Roles Conceptualization, Data curation

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Liyuan Ru,

  Roles Conceptualization, Methodology

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Ziyue Guo,

  Roles Validation

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Shilong Han,

  Roles Conceptualization, Methodology

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  ⨯
• Wuguo Deng ,

  Roles Data curation, Project administration, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: dengwg@sysucc.org.cn (WD); linfei@sysucc.org.cn (FL); wei1015@dmu.edu.cn (WG)

  Affiliation Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China

  ⨯
• Fei Lin ,

  Roles Writing – review & editing

  * E-mail: dengwg@sysucc.org.cn (WD); linfei@sysucc.org.cn (FL); wei1015@dmu.edu.cn (WG)

  Affiliation Department of Oncology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine; The Affiliated Nanhai Hospital of Traditional Chinese Medicine of Jinan University, Foshan, China

  ⨯
• Wei Guo

  Roles Conceptualization, Funding acquisition, Investigation, Validation, Writing – review & editing

  * E-mail: dengwg@sysucc.org.cn (WD); linfei@sysucc.org.cn (FL); wei1015@dmu.edu.cn (WG)

  Affiliation Institute of Cancer Stem Cells & The First Affiliated Hospital, Dalian Medical University, Dalian, China

  https://orcid.org/0000-0003-1662-0194

  ⨯