The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission

Jiajia He; Ke Liu; Yifan Wu; Chenhui Zhao; Shuaijie Yan; Jia-Hui Chen; Lizhu Hu; Dongmei Wang; Fan Zheng; Wenfan Wei; Chao Xu; Chengdong Huang; Xing Liu; Xuebiao Yao; Lijun Ding; Zhiyou Fang; Ai-Hui Tang; Chuanhai Fu

doi:10.1371/journal.pbio.3002247

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Open Access

Peer-reviewed

Research Article

The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission

Jiajia He ,

Contributed equally to this work with: Jiajia He, Ke Liu

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
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Ke Liu ,

Contributed equally to this work with: Jiajia He, Ke Liu

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
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Yifan Wu,

Roles Investigation

Affiliation MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
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Chenhui Zhao,

Roles Investigation

Affiliation MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
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Shuaijie Yan,

Roles Investigation

Affiliation MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
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Jia-Hui Chen,

Roles Investigation

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China
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Lizhu Hu,

Roles Investigation

Affiliation Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China
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Dongmei Wang,

Roles Investigation

Affiliation MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
⨯
Fan Zheng,

Roles Investigation

Affiliation MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
⨯
Wenfan Wei,

Roles Investigation

Affiliation MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
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Chao Xu,

Roles Methodology, Writing – review & editing

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
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Chengdong Huang,

Roles Methodology, Writing – review & editing

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
⨯
Xing Liu,

Roles Methodology, Writing – review & editing

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
⨯
Xuebiao Yao,

Roles Funding acquisition, Writing – review & editing

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China
⨯
Lijun Ding,

Roles Methodology, Writing – review & editing

Affiliation Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
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Zhiyou Fang ,

Roles Supervision, Writing – original draft

* E-mail: z.fang@cmpt.ac.cn (ZF); tangah@ustc.edu.cn (A-HT); chuanhai@ustc.edu.cn (CF)

Affiliation Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China
⨯
Ai-Hui Tang ,

Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: z.fang@cmpt.ac.cn (ZF); tangah@ustc.edu.cn (A-HT); chuanhai@ustc.edu.cn (CF)

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China
⨯
[ ... ],
Chuanhai Fu

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: z.fang@cmpt.ac.cn (ZF); tangah@ustc.edu.cn (A-HT); chuanhai@ustc.edu.cn (CF)

Affiliations MOE Key Laboratory for Cellular Dynamics & Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, Anhui Key Laboratory of Cellular Dynamics and Chemical Biology & Hefei National Research Center for Interdisciplinary Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China

https://orcid.org/0000-0003-4354-3796

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The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission

Jiajia He,
Ke Liu,
Yifan Wu,
Chenhui Zhao,
Shuaijie Yan,
Jia-Hui Chen,
Lizhu Hu,
Dongmei Wang,
Fan Zheng,
Wenfan Wei

Published: August 17, 2023
https://doi.org/10.1371/journal.pbio.3002247

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