Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Dong Han; Wei Wang; Julie Heejin Jeon; Tao Shen; Xiangsheng Huang; Ping Yi; Bingning Dong; Feng Yang

doi:10.1371/journal.pbio.3002227

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Open Access

Peer-reviewed

Research Article

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Dong Han ,

Contributed equally to this work with: Dong Han, Wei Wang

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Wei Wang ,

Contributed equally to this work with: Dong Han, Wei Wang

Roles Data curation

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Julie Heejin Jeon,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Tao Shen,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Xiangsheng Huang,

Roles Data curation

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Ping Yi,

Roles Investigation, Writing – review & editing

Affiliation Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States of America
⨯
Bingning Dong,

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Feng Yang

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: fyang@bcm.edu

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America

https://orcid.org/0000-0002-3401-5783

⨯

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Dong Han,
Wei Wang,
Julie Heejin Jeon,
Tao Shen,
Xiangsheng Huang,
Ping Yi,
Bingning Dong,
Feng Yang

Published: August 2, 2023
https://doi.org/10.1371/journal.pbio.3002227

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