Structural basis of G protein–Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist

Xuan Zhang; Tina Weiß; Mary Hongying Cheng; Siqi Chen; Carla Katharina Ambrosius; Anne Sophie Czerniak; Kunpeng Li; Mingye Feng; Ivet Bahar; Annette G. Beck-Sickinger; Cheng Zhang

doi:10.1371/journal.pbio.3002188

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Open Access

Peer-reviewed

Research Article

Structural basis of G protein–Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist

Xuan Zhang ,

Contributed equally to this work with: Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen

Roles Investigation, Writing – review & editing

Affiliation Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Tina Weiß ,

Contributed equally to this work with: Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen

Roles Investigation, Writing – review & editing

Affiliation Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany
⨯
Mary Hongying Cheng ,

Contributed equally to this work with: Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Siqi Chen ,

Contributed equally to this work with: Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen

Roles Investigation, Writing – review & editing

Affiliation Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Carla Katharina Ambrosius,

Roles Investigation

Affiliation Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany
⨯
Anne Sophie Czerniak,

Roles Investigation

Affiliation Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany
⨯
Kunpeng Li,

Roles Investigation

Affiliation Cryo-EM core facility, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Mingye Feng ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mfeng@coh.org (MF); bahar@laufercenter.org (IB); abeck-sickinger@uni-leipzig.de (AGB-S); chengzh@pitt.edu (CZ)

Affiliation Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Ivet Bahar ,

Roles Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mfeng@coh.org (MF); bahar@laufercenter.org (IB); abeck-sickinger@uni-leipzig.de (AGB-S); chengzh@pitt.edu (CZ)

Affiliations Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, United States of America, Department of Biochemistry and Cell Biology, School of Medicine, Stony Brook University, Stony Brook, New York, United States of America
⨯
Annette G. Beck-Sickinger ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mfeng@coh.org (MF); bahar@laufercenter.org (IB); abeck-sickinger@uni-leipzig.de (AGB-S); chengzh@pitt.edu (CZ)

Affiliation Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany
⨯
Cheng Zhang

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mfeng@coh.org (MF); bahar@laufercenter.org (IB); abeck-sickinger@uni-leipzig.de (AGB-S); chengzh@pitt.edu (CZ)

Affiliation Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0001-9042-4007

⨯

Structural basis of G protein–Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist

Xuan Zhang,
Tina Weiß,
Mary Hongying Cheng,
Siqi Chen,
Carla Katharina Ambrosius,
Anne Sophie Czerniak,
Kunpeng Li,
Mingye Feng,
Ivet Bahar,
Annette G. Beck-Sickinger

Published: December 6, 2023
https://doi.org/10.1371/journal.pbio.3002188

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