Rab26 restricts insulin secretion via sequestering Synaptotagmin-1

Ruijuan Zhuang; Yuxia Zhou; Ziyan Wang; Yating Cao; Jun Chen; Liju Xu; Yandan Ren; Yige Zheng; Ziheng Wei; Hantian Qiu; Liangcheng Li; Yang Han; Ye Yun; Xin Chen; Wanjin Hong; Tuanlao Wang

doi:10.1371/journal.pbio.3002142

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Open Access

Peer-reviewed

Research Article

Rab26 restricts insulin secretion via sequestering Synaptotagmin-1

Ruijuan Zhuang ,

Contributed equally to this work with: Ruijuan Zhuang, Yuxia Zhou

Roles Data curation, Investigation

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Yuxia Zhou ,

Contributed equally to this work with: Ruijuan Zhuang, Yuxia Zhou

Roles Investigation, Validation

Affiliation School of Basic Medical Sciences, Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, China
⨯
Ziyan Wang,

Roles Investigation

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Yating Cao,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian, China
⨯
Jun Chen,

Roles Methodology

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Liju Xu,

Roles Investigation

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Yandan Ren,

Roles Methodology

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Yige Zheng,

Roles Investigation

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Ziheng Wei,

Roles Investigation

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Hantian Qiu,

Roles Data curation

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Liangcheng Li,

Roles Project administration

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Yang Han,

Roles Methodology

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Ye Yun,

Roles Methodology

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China
⨯
Xin Chen ,

Roles Data curation, Funding acquisition

* E-mail: xchen@xmu.edu.cn (XC); mcbhwj@imcb.a-star.edu.sg (WH); xmuibrwtl@xmu.edu.cn (TW)

Affiliation State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian, China
⨯
Wanjin Hong ,

Roles Conceptualization, Resources, Writing – review & editing

* E-mail: xchen@xmu.edu.cn (XC); mcbhwj@imcb.a-star.edu.sg (WH); xmuibrwtl@xmu.edu.cn (TW)

Affiliations School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China, Institute of Molecular and Cell Biology, A STAR (Agency of Science, Technology and Research), Singapore, Singapore
⨯
[ ... ],
Tuanlao Wang

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft

* E-mail: xchen@xmu.edu.cn (XC); mcbhwj@imcb.a-star.edu.sg (WH); xmuibrwtl@xmu.edu.cn (TW)

Affiliation School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China

https://orcid.org/0000-0001-5375-1615

⨯
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Rab26 restricts insulin secretion via sequestering Synaptotagmin-1

Ruijuan Zhuang,
Yuxia Zhou,
Ziyan Wang,
Yating Cao,
Jun Chen,
Liju Xu,
Yandan Ren,
Yige Zheng,
Ziheng Wei,
Hantian Qiu

Published: June 8, 2023
https://doi.org/10.1371/journal.pbio.3002142

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