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Open Access
Peer-reviewed
Research Article
Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
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Christopher E. Morgan,
Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Current address: Department of Chemistry and Physics, Thiel College, Greenville, Pennsylvania, United States of America
Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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Yoon-Suk Kang ,
Contributed equally to this work with: Yoon-Suk Kang, Alex B. Green, Kenneth P. Smith
Roles Investigation, Methodology
Affiliations Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Alex B. Green ,
Contributed equally to this work with: Yoon-Suk Kang, Alex B. Green, Kenneth P. Smith
Roles Investigation, Methodology
Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Kenneth P. Smith ,
Contributed equally to this work with: Yoon-Suk Kang, Alex B. Green, Kenneth P. Smith
Roles Formal analysis, Investigation, Methodology
Current address: Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Affiliations Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Matthew G. Dowgiallo,
Roles Investigation, Methodology
Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America
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Brandon C. Miller,
Roles Investigation, Methodology
Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America
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Lucius Chiaraviglio,
Roles Investigation, Methodology
Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Katherine A. Truelson,
Roles Investigation, Methodology
Current address: Graduate Program in Biology, Boston College, Boston, MA, United States of America
Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Katelyn E. Zulauf,
Roles Investigation, Methodology, Supervision
Current address: Locus Biosciences, Morrisville, North Carolina, United States of America
Affiliations Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Shade Rodriguez,
Roles Investigation, Methodology
Current address: Graduate Program in Pathobiology, Brown University, Providence, Rhode Island, United States of America
Affiliation Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Anthony D. Kang,
Roles Investigation, Methodology
Current address: DIU, Mountain View, California, United States of America
Affiliations Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Roman Manetsch,
Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing
Affiliations Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America, Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, United States of America, Center for Drug Discovery, Northeastern University, Boston, Massachusetts, United States of America
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Edward W. Yu,
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing
Affiliation Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
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James E. Kirby
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jekirby@bidmc.harvard.edu
Affiliations Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
- Christopher E. Morgan,
- Yoon-Suk Kang,
- Alex B. Green,
- Kenneth P. Smith,
- Matthew G. Dowgiallo,
- Brandon C. Miller,
- Lucius Chiaraviglio,
- Katherine A. Truelson,
- Katelyn E. Zulauf,
- Shade Rodriguez
- Published: May 16, 2023
- https://doi.org/10.1371/journal.pbio.3002091