Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis

Xinli Wang; Xuxia Wei; Yan Lu; Qinghuan Wang; Rong Fu; Yin Wang; Qin Wang; Xiangyan Wang; Shangwu Chen; Anlong Xu; Shaochun Yuan

doi:10.1371/journal.pbio.3002062

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Open Access

Peer-reviewed

Research Article

Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis

Xinli Wang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China, Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao, People’s Republic of China
⨯
Xuxia Wei,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China, Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao, People’s Republic of China
⨯
Yan Lu,

Roles Investigation

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Qinghuan Wang,

Roles Investigation

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Rong Fu,

Roles Investigation

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Yin Wang,

Roles Investigation

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Qin Wang,

Roles Investigation

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Xiangyan Wang,

Roles Investigation

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Shangwu Chen,

Roles Writing – review & editing

Affiliation Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
⨯
Anlong Xu ,

Roles Conceptualization, Project administration, Writing – review & editing

* E-mail: lssxal@mail.sysu.edu.cn (AX); yuanshch@mail.sysu.edu.cn (SY)

Affiliations Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China, School of Life Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of China

https://orcid.org/0000-0002-1419-3494

⨯
Shaochun Yuan

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: lssxal@mail.sysu.edu.cn (AX); yuanshch@mail.sysu.edu.cn (SY)

Affiliations Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China, Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao, People’s Republic of China
⨯

Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis

Xinli Wang,
Xuxia Wei,
Yan Lu,
Qinghuan Wang,
Rong Fu,
Yin Wang,
Qin Wang,
Xiangyan Wang,
Shangwu Chen,
Anlong Xu

Published: May 3, 2023
https://doi.org/10.1371/journal.pbio.3002062

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