Adaptive β-lactam resistance from an inducible efflux pump that is post-translationally regulated by the DjlA co-chaperone

Jordan Costafrolaz; Gaël Panis; Bastien Casu; Silvia Ardissone; Laurence Degeorges; Martin Pilhofer; Patrick H. Viollier

doi:10.1371/journal.pbio.3002040

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Open Access

Peer-reviewed

Research Article

Adaptive β-lactam resistance from an inducible efflux pump that is post-translationally regulated by the DjlA co-chaperone

Jordan Costafrolaz,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
⨯
Gaël Panis,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
⨯
Bastien Casu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Biology, Institute of Molecular Biology & Biophysics, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland
⨯
Silvia Ardissone,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
⨯
Laurence Degeorges,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
⨯
Martin Pilhofer,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Biology, Institute of Molecular Biology & Biophysics, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland
⨯
Patrick H. Viollier

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: patrick.viollier@unige.ch

Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire, University of Geneva, Geneva, Switzerland

https://orcid.org/0000-0002-5249-9910

⨯

Adaptive β-lactam resistance from an inducible efflux pump that is post-translationally regulated by the DjlA co-chaperone

Jordan Costafrolaz,
Gaël Panis,
Bastien Casu,
Silvia Ardissone,
Laurence Degeorges,
Martin Pilhofer,
Patrick H. Viollier

Published: December 5, 2023
https://doi.org/10.1371/journal.pbio.3002040

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Immunoblotting
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Electrophoretic mobility shift assay
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