TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

Yuka Koike; Sarah Pickles; Virginia Estades Ayuso; Karen Jansen-West; Yue A. Qi; Ziyi Li; Lillian M. Daughrity; Mei Yue; Yong-Jie Zhang; Casey N. Cook; Dennis W. Dickson; Michael Ward; Leonard Petrucelli; Mercedes Prudencio

doi:10.1371/journal.pbio.3002028

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Open Access

Peer-reviewed

Research Article

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

Yuka Koike,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America
⨯
Sarah Pickles,

Roles Resources, Writing – review & editing

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America
⨯
Virginia Estades Ayuso,

Roles Formal analysis, Investigation, Validation

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Karen Jansen-West,

Roles Investigation, Methodology, Resources, Supervision

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Yue A. Qi,

Roles Data curation, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

Affiliation Center for Alzheimer’s and Related Dementias, National Institute on Aging, NIH, Bethesda, Maryland, United States of America
⨯
Ziyi Li,

Roles Data curation, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

Affiliation Center for Alzheimer’s and Related Dementias, National Institute on Aging, NIH, Bethesda, Maryland, United States of America
⨯
Lillian M. Daughrity,

Roles Methodology, Resources, Validation

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Mei Yue,

Roles Resources

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Yong-Jie Zhang,

Roles Resources, Supervision

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America
⨯
Casey N. Cook,

Roles Resources, Supervision

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America
⨯
Dennis W. Dickson,

Roles Resources

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America
⨯
Michael Ward,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Center for Alzheimer’s and Related Dementias, National Institute on Aging, NIH, Bethesda, Maryland, United States of America, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, United States of America
⨯
Leonard Petrucelli ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: Petrucelli.Leonard@mayo.edu (LP); prudencio.mercedes@mayo.edu (MP)

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America

https://orcid.org/0000-0003-2959-129X

⨯
Mercedes Prudencio

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Petrucelli.Leonard@mayo.edu (LP); prudencio.mercedes@mayo.edu (MP)

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, Florida, United States of America

https://orcid.org/0000-0002-4894-4858

⨯

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

Yuka Koike,
Sarah Pickles,
Virginia Estades Ayuso,
Karen Jansen-West,
Yue A. Qi,
Ziyi Li,
Lillian M. Daughrity,
Mei Yue,
Yong-Jie Zhang,
Casey N. Cook

Published: March 17, 2023
https://doi.org/10.1371/journal.pbio.3002028

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