Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer’s disease pathology in mice

• Huilong Yin ,

  Contributed equally to this work with: Huilong Yin, Zhuan Ju

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China, The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi’an, Shaanxi, China, The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Zhuan Ju ,

  Contributed equally to this work with: Huilong Yin, Zhuan Ju

  Roles Investigation, Validation, Visualization

  Affiliation Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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• Minhua Zheng,

  Roles Investigation, Methodology

  Affiliation The State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Xiang Zhang,

  Roles Investigation

  Affiliation The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Wenjie Zuo,

  Roles Investigation

  Affiliations Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China, Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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• Yidi Wang,

  Roles Investigation

  Affiliation Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Xiaochen Ding,

  Roles Methodology

  Affiliation Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Xiaofang Zhang,

  Roles Methodology

  Affiliation The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Yingran Peng,

  Roles Investigation

  Affiliation The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Jiadi Li,

  Roles Investigation

  Affiliation Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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• Angang Yang ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  * E-mail: agyang@fmmu.edu.cn (AY); ruizhang@fmmu.edu.cn (RZ)

  Affiliations Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China, The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi’an, Shaanxi, China, The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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• Rui Zhang

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  * E-mail: agyang@fmmu.edu.cn (AY); ruizhang@fmmu.edu.cn (RZ)

  Affiliations The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi’an, Shaanxi, China, The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi, China

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